• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
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  • 优先权
    • 专利摘要:
    INTRAOCULAR PRESSURE MONITORING DEVICE, INTRAOCULAR PRESSURE MONITORING SYSTEM AND KIT Monitoring device for intraocular pressure comprising a soft contact lens (1) and a pressure sensor connected with the contact lens (1), in which the sensor The pressure gauge comprises an active pressure gauge (2), a passive gauge (3), a rigid element (4) and a microprocessor (5). The active pressure gauge (2), the passive gauge (3) and the rigid element (4) are placed at a distance from the center (C) of the contact lens, where the active pressure gauge (2) comprises a portion that surrounds the center (C) of the contact lens (1) by at least 180 °, each between the passive meter (3) and the rigid element (4) comprises a part that surrounds the center (C) of the contact lens contact (1) at least 180 ° and the passive meter part (3) located around the center (C) of the contact lens (1) is placed in the immediate vicinity of the rigid element part (4) located around the center (C) of the contact lenses (1). Kit comprising this pressure monitoring device and a portable recording device (6) configured to communicate with the pressure monitoring device and to store data from it (...).
    公开号:BR112012016419B1
    申请号:R112012016419-8
    申请日:2011-01-03
    公开日:2020-12-29
    发明作者:Sacha Cerboni
    申请人:Sensimed Sa；
    IPC主号:
    专利说明:

    [1] The present invention relates to an intraocular pressure monitoring (IOP) device. The present invention particularly relates to a device that can be placed over the user's eye to monitor intraocular pressure over an extended period of time, such as 24 hours or more. The present invention also relates to a kit and an intraocular pressure monitoring (IOP) system.
    [2] Glaucoma is a disseminated disease characterized by high intraocular pressure (IOP). This elevated IOP produces a gradual loss of peripheral vision. Therefore, there is a need for detailed knowledge of IOP in patients with glaucoma in order to provide a reliable diagnosis or establish new therapies.
    [3] Patent EP 1401327 describes an intraocular pressure recording system comprising a soft contact lens and a pressure sensor attached to the contact lens. The pressure sensor comprises an active pressure gauge that is located around the center of the contact lens, in order to allow measurement of the spherical deformations of the eyeball that are due to IOP changes. In one embodiment, the pressure sensor comprises two active pressure gauges and two passive gauges placed in a Wheatstone bridge configuration. Active pressure gauges are circular gauges located around the center of the contact lens, while passive gauges are placed essentially radially to the lens to minimize deformation when the eyeball is deformed. Passive meters are made up of a plurality of radial segments located on one side of the contact lens, which are interconnected by short and substantially tangent segments.
    [4] A disadvantage of this intraocular pressure recording system is the fact that it is difficult to optimize the sensor's characteristics without compromising user comfort. For passive measurement to be as insensitive as possible to deformations of the eyeball, the radial segments must be as long as possible with respect to the tangent segments. Their length, however, is limited, as if they are too close to the center of the lens, they will be within the user's view. In addition, even if the length of the radial segments is correctly limited for standard contact lens use, it is not possible to exclude situations in which the user's vision may be impaired by passive meters, such as if the contact lens accidentally slides only slightly over the eye or in a dark environment, in which the user's pupil is particularly dilated.
    [5] Another disadvantage of this intraocular pressure recording system is the fact that the asymmetric design of passive measurements in relation to the center of the contact lens can generate temporary or permanent asymmetric deformations of the contact lens itself, which can then lose its its spherical shape, and thus result in discomfort for the user who uses the lens.
    [6] Yet another disadvantage of the EP1401327 intraocular pressure recording system is the fact that the position and shape of passive meters are very different from active pressure meters. The influence of variations in environmental factors other than IOP, such as temperature, humidity, etc., on the physical properties of passive measurements may therefore differ significantly from the influence of the same variations on the physical properties of active pressure gauges, in a induce errors or inaccuracies when determining IOP.
    [7] An object of the present invention is, therefore, to provide an intraocular pressure monitoring device that can be used for extended periods of time and in any situation without great discomfort for the user.
    [8] Another object of the present invention is the provision of an intraocular pressure monitoring device that provides an accurate measurement of IOP.
    [9] Yet another object of the present invention is the provision of a kit and an intraocular pressure monitoring system that can provide an accurate measurement of IOP over an extended period of time.
    [10] These objects and other advantages are achieved by a device, kit and system that comprises the characteristics of the corresponding independent claims.
    [11] These objects are particularly affected by an intraocular pressure monitoring device that comprises a soft contact lens and a pressure sensor connected with the contact lens, where the pressure sensor comprises an active pressure gauge, a gauge passive, a rigid element and a microprocessor. The active pressure gauge, the passive gauge and the rigid element are placed at a distance from the center of the contact lens, where the active pressure gauge comprises a part that surrounds the center of the contact lens by at least 180 °, each one of the passive meter and the rigid element comprises a part that surrounds the center of the contact lens by at least 180 ° and the part of the passive meter located around the center of the contact lens is placed in the immediate vicinity of the part of the rigid element located around the center of the contact lens.
    [12] These objects are also hit by a kit comprising this pressure monitoring device and a portable recording device configured to communicate with the pressure monitoring device and to store data received from it.
    [13] These objects are also reached by an intraocular pressure monitoring system comprising this kit and a computing device configured to communicate with the portable recording device to receive and / or process and / or store data received from the recording device. portable.
    [14] According to the present invention, the intraocular pressure monitoring device comprising a rigid element to make a part of the contact lens rigid allows the placement of the passive meter in the vicinity of that rigid element around the center of the contact lens, in order to allow a format of passive meters that do not hinder the user's vision and also allow the format of passive meters with a configuration similar to that of the active meter, in order to provide more efficient and reliable correction of the variations measured by the active meter that are due to environmental factors and not to IOP variations.
    [15] After placing the passive meter in the immediate vicinity of the rigid element, its shape can be freely selected with almost no restrictions, as its resistance to deformation of the eyeball of a user using the device according to the present invention is provided by the rigid element and not by its shape and / or position or orientation on the contact lens. This allows, for example, the shape of a passive meter located around the center of the contact lens, which is essentially symmetrical with respect to the center of the contact lens. In addition, the passive meter can be designed and positioned similarly to the active pressure meter. The passive meter can be, for example, an essentially continuous conductor, such as circular or polygonal, which is located at least in part around the center of the lens. The passive meter can then be placed easily at a distance from the center of the contact lens sufficient to not disturb the user.
    [16] The present invention will be better understood with the aid of the following description, illustrated by the figures, in which: - figure 1 illustrates an intraocular pressure monitoring device according to a preferred embodiment of the present invention; figure 2 is a sectional view of the device of figure 1 along line II-II; figure 3 shows an intraocular pressure monitoring device according to another embodiment of the present invention; figure 4 shows an example of a possible configuration of a passive and / or active pressure gauge according to the present invention; - the figures. 5a and 5b illustrate two possible variants of embodiments of the configuration of a passive and / or active pressure gauge according to the present invention; and - figure 6 is a schematic representation of an intraocular pressure monitoring system according to the present invention.
    [17] The same reference figures in different figures designate identical or similar elements.
    [18] According to a preferred embodiment illustrated in figure 1, the intraocular monitoring device according to the present invention comprises a pressure sensor attached to a contact lens 1, preferably a soft contact lens. When contact lens 1 is used by a user, the pressure sensor is placed over the user's eyeball. In order to avoid any discomfort for the user, the pressure sensor elements are preferably not in direct contact with the eye. The sensor is, for example, embedded or embedded in the contact lens 1 or attached to the external convex surface of the contact lens 1, or one of its combinations, in which some elements of the sensor are embedded in the contact lens 1 and others are attached on its surface.
    [19] According to other less advantageous embodiments of the present invention, however, the pressure sensor elements are fixed, in whole or in part, on the internal concave surface of the contact lens 1 and, therefore, are in contact at least partial with the eye of the wearer using the contact lens 1.
    [20] All elements of the pressure sensor are preferably placed at a sufficient distance from the center C of the contact lens 1 so that they do not disturb the vision of a user using the device according to the present invention, in such a way that the device according to the present invention can be used without disturbances and / or significant discomfort for the user over extended periods of time, for example, ten hours, 24 hours or even a few days, in the same way as any contact lens habitual.
    [21] The pressure sensor comprises an active pressure gauge 2, a passive gauge 3, a rigid element 4 and a microprocessor 5.
    [22] Contact lens 1 is preferably a soft contact lens, made, for example, from a waterproof and / or silicone-based material, which adheres to the eyeball with relatively high adhesion force. Variations in intraocular pressure (IOP) generate deformations of the user's eyeball. Typically, when the IOP rises, the eyeball expands, and when the IOP decreases, the eyeball contracts. When the device according to the present invention is used by the user, the deformations of his eyeball induce deformations of the contact lens 1 that is in close contact with the eyeball, where the amplitude of the deformations of the contact lens 1 is bigger on its periphery.
    [23] The active pressure gauge 2 is configured and located on the contact lens 1, so that it is subjected to deformations of the contact lens 1. According to the present invention, a part of the active pressure gauge 2 is placed around the center C of the contact lens 1 and at least partially surrounds the center C. The active pressure gauge 2 describes or therefore covers an arc of circumference which is preferably centered on the center C of the contact lens 1.
    [24] The general shape of the part of the active pressure gauge 2 that is placed around the center C is that of an arc of circumference. The configuration of this part may, however, vary within the scope of the present invention, depending, for example, on the electrical properties sought from the active pressure gauge 2, the method used for its manufacture, the location available on the contact lens, etc. The part of the active pressure gauge 2 that is placed around the center C is made, for example, of one or more circular or curved segments that form one or more concentric arcs or of one or more straight segments that form, for example, one or more parts of a polygon, a canvas or any other adapted format. A combination of one or more of the above formats is also possible within the scope of the present invention.
    [25] Regardless of its configuration, the part of the active pressure gauge 2 that is placed around the center C preferably covers an arc of at least 180 ° around the mentioned center C, in order to surround the center C in at least 180 °, that is, over at least half of its periphery, in order to provide sufficient and reliable verification of the contact lens deformations that are due to IOP variations and therefore in order to provide a reliable measurement of IOP variations.
    [26] IOP variations induce deformations of the contact lens 1 used by the user. The contact lens 1 is stretched when the IOP rises and is contracted when reduced or decreased, in order to indicate a variation in the diameter of the contact lens. In order to reliably detect these variations in diameters, the part of the active meter 2 that is placed around the center C therefore preferably covers an arc of at least 180 °. This allows the active meter 2, regardless of its local configuration, to detect variations in diameters of the contact lens 1 instead of local deformations that could be due to local conditions that are not related to IOP variations.
    [27] Preferably even greater, in order to maximize the length of the part of the active pressure gauge 2 that is placed around the center C, in order to maximize the sensitivity of the active pressure gauge 2, the part of the pressure gauge active 2 which is placed around center C covers as much as possible an entire circle around center C. According to a preferred embodiment of the present invention, the part of the active pressure gauge 2 which is placed around center C surrounds preferably, therefore, the center C of the contact lens 1 by at least 270 °, that is, it covers an arc of at least 270 ° around said center C, in which a segment of the contact lens 1 is used by the connections essentially dimensions of the active pressure gauge 2 and other elements of the pressure sensor to the microprocessor 5.
    [28] In a preferred embodiment, the active pressure gauge is a relatively thin and essentially circular electrical conductor placed at the periphery of the contact lens 1. The two ends of the active pressure gauge 2 are in electrical contact with the microprocessor 5 The section of the active pressure gauge part 2 that is placed around the center C of the contact lens 1 is selected as being small enough that the active pressure gauge is deformable when subjected to the effects of IOP variations. Preferably, the elasticity of the active pressure gauge 2 is equal to or close to the elasticity of the contact lens 1. Preferably even greater, the elasticity of the active pressure gauge 2 is equal to or higher than the elasticity of the contact lens 1. O active pressure gauge 2 is preferably made by stripping, printing and / or cutting a thin sheet of metal. In a variant embodiment, the active pressure gauge 2 is made of a thin metallic wire. In yet another embodiment, the active pressure gauge is made by depositing metal and / or any other electrically conductive material on a preferably flexible and transparent substrate, such as on a polyimide film 10.
    [29] According to the present invention and as explained above, where the active pressure gauge 2 is attached to the contact lens 1, the deformations of the contact lens 1 induce deformations of the active pressure gauge 2, in order to modify its physical properties, particularly its electrical properties. If the IOP rises and the eyeball expands, for example, the contact lens 1 is extended at its periphery and the active pressure gauge 2 is stretched. This creates a reduction in the section of the active pressure gauge part 2 placed around the center C of the contact lens 1 and therefore an increase in its electrical resistance. By measuring the changes in electrical resistance of the active pressure gauge 2, it is possible to detect and measure changes in IOP.
    [30] Microprocessor 5 is programmed to measure the electrical resistance of the active pressure gauge 2 using methods known in the art.
    [31] Factors other than deformation of the eyeball and therefore of the contact lens 1 can, however, affect the electrical resistance of the active pressure gauge 2, particularly environmental parameters such as temperature, humidity, ambient pressure, etc.
    [32] According to the present invention, the pressure sensor according to the present invention comprises a passive meter 3 to measure only the effects of these other factors, particularly to measure the effects of environmental parameters. According to the present invention, the passive meter 3 has a nature and configuration preferably similar to the active pressure meter 2, such that the effects of environmental parameters on their physical properties are identical or at least similar to the effects of these same parameters on properties physical characteristics of the active pressure gauge 2. In particular, the passive gauge 3 is preferably made of the same material and according to the same technology or manufacturing process as the active gauge 2 and the shape and configuration of the passive gauge 3 are preferably the same or at least similar to the shape and configuration of the active meter 2. The passive meter therefore also comprises a part placed around the center C of the contact lens 1 that preferably covers an arc at an angle close to the angle of the arc covered by the active meter two.
    [33] According to the example shown in figure 1, the passive meter 3 is, for example, a thin and essentially circular electrical conductor placed around the center C of the contact lens 1. The passive meter 3 is preferably positioned closer to the center C of the contact lens 1 that the pressure gauge is active 2. The two ends of the passive gauge 3 are in electrical contact with the microprocessor 5.
    [34] Other configurations of the passive meter 3 are possible within the scope of the present invention, in which the configuration of the passive meter 3 is preferred but not necessarily similar to that of the active meter 2. In particular the part of the passive meter 3 that is placed in around center C is made, for example, of one or more circular or curved segments that form one or more concentric arcs or of one or more straight segments that form, for example, one or more parts of a polygon, a canvas or any another adapted format. A combination of one or more of the above formats is also possible within the scope of the present invention.
    [35] According to preferred embodiments of the present invention, the passive meter 3 has a configuration similar to that of the active meter 2 and, preferably, covers an arc with an angle close to the angle of the arc covered by the active pressure meter 2, that is, the meter passive 3 preferably surrounds the center C of the contact lens at an angle close to the angle at which the active meter 2 surrounds the center C of the contact lens 1. The deformations induced in the passive meter 3 through possible variations in environmental conditions are, therefore, similar to those induced by these same variations in the active meter 2. The effects of changes in the environmental conditions of the electrical properties of the passive meter 3 are, therefore, representative of the effects of changes in the same environmental conditions on the electrical properties of the active meter 2.
    [36] The part of the passive meter 3 that is placed around the center C of the contact lens 1 preferably covers, therefore, an arc of at least 180 °, that is, it surrounds the center C of the contact lens by 180 °. Even more preferably, the part of the passive meter 3 that is placed around the center C covers an arc of at least 270 ° around the mentioned center C, that is, it surrounds the center C of the contact lens by at least 270 ° .
    [37] In order to avoid or at least minimize any deformation of the passive meter 3 due to IOP variations, the pressure sensor according to the present invention additionally comprises a rigid element 4 which has a part located around the center C of the contact lens 1. The rigid element 4, preferably, is sufficiently rigid to not be subjected to significant deformations when the user's eyeball is deformed. According to the present invention, the passive meter part 3 placed around the center C of the contact lens 1 is in the immediate vicinity of the part of the rigid element 4 placed around the center C of the contact lens 1. The meter part passive 3 placed around the center C of the contact lens 1 is therefore located in a region of the contact lens 1 that is stiffened by the rigid element 4 and, as such, is not or is only marginally subjected to deformation due to variations in IOP. The physical properties of the passive meter 3, therefore, are not noticeably modified when the eyeball is deformed due to variations in IOP. Any observable change in the physical properties of the passive meter 3, particularly in its electrical resistance, can therefore be considered to be due to other factors, particularly variations in environmental parameters.
    [38] Variations in physical properties measured on the active pressure gauge 2 can therefore be corrected by variations in the physical properties measured on the passive gauge 3 in order to determine the variations that are actually necessary due to variations in the IOP. The variations in intraocular pressure are therefore determined, for example, based on the result of subtracting the measured variations in the electrical resistance of the active pressure meter 2 from the measured variations in the electrical resistance of the passive meter 3, possibly multiplied or otherwise corrected. by a calibration factor.
    [39] In this specification, the term "active pressure gauge" or "active gauge" designates a pressure gauge of the device's pressure sensor according to the present invention that is used to check the deformations of the user's eyeball and therefore, the contact lens due to variations in the user's IOP. The active pressure gauge is therefore configured and placed on the device according to the present invention, particularly on the contact lens, so that it is as sensitive as possible to these deformations.
    [40] The term "passive pressure gauge" or "passive gauge" means, however, a pressure gauge of the device's pressure sensor according to the present invention that is as insensitive as possible to the eyeball deformations that are due variations in the user's IOP. Possible variations in the physical properties of the passive pressure gauge are preferably due, therefore, only to variations in environmental conditions. The term "passive" refers, therefore, to the fact that the pressure gauge measures only variations that are due to environmental conditions and is only marginally subjected to deformations due to variations in IOP.
    [41] According to the preferred embodiment shown in Figure 1, the rigid element 4 is an elaborate antenna, for example, with three concentric conductors placed around the center C of the contact lens 1, each made of a circular segment and each one in electrical contact on both ends with microprocessor 5. The antenna allows, for example, the wireless transmission of signals between microprocessor 5 and an external controller to measure and record IOP variations over time. Preferably, antenna 4 additionally allows the supply of electrical energy to microprocessor 5 by means of known induction power methods.
    [42] According to an embodiment of the present invention, when microprocessor 5 is switched on, the electrical resistance of the active pressure gauge 2 and the passive gauge 3 is measured and possibly processed in microprocessor 5, in order to determine an IOP value, either an absolute or relative IOP value. The measured resistance values and / or the determined IOP value are then sent by antenna 4 to the external controller for processing and / or registration. Preferably, the measurement cycles are initiated by the external controller and performed at regular intervals, in order to allow regular monitoring of intraocular pressure. The frequency of IPO measurements depends on needs, for example, for diagnostic and / or experimental purposes, and is preferably determined by configuring the external controller.
    [43] In the preferred embodiment shown in Figure 1, the rigid element 4 is an electrically conductive element installed around the center C and concentric with the passive meter 3 and the active pressure meter 2. The configuration of the rigid element part 4 which is positioned around the center C is preferably similar to that of meters 2, 3, but with a significantly larger section, which makes it less elastic than meters 2, 3 and therefore preferably resistant to deformations of the eyeball due to variations of IOP. The rigid element 4 also serves, for example, as an antenna for the pressure sensor for wireless communication with an external controller.
    [44] The active pressure gauge 2 preferably rests along the periphery of the contact lens 1, where the amplitude of the deformations of the contact lens 1 due to IOP variations is the largest. The rigid element 4 and the passive meter 3 are preferably closer to the center C than the active pressure meter 2, although they do not interfere with the vision of the user using the device according to the present invention. The rigid element 4 thus stiffens a central part of the contact lens 1. Preferably, the passive meter 3 is located in the immediate vicinity of the rigid element 4, preferably along the inner side of the rigid element 4. In a variant embodiment, the passive meter 3 is located at least partially between two concentric parts of the rigid element 4, for example, between two rings of the antenna.
    [45] Other types of rigid elements are, however, possible within the scope of the present invention, in order to stiffen the part of the contact lens where the passive meter is located. In particular, the rigid element may have no function other than mechanical. The rigid element can, for example, be an element with very low elasticity, placed in the immediate vicinity of the passive meter 3 or even attached to it, where the rigid element is, for example, a relatively rigid substrate on which the passive meter 3 is affixed or grown by means of deposition, such as by means of deposition of metallic vapor. The rigid element is, for example, a plastic element, metallic synthetic or any other rigid with no other function than to stiffen a part of the contact lens, in order to preserve the passive meter against deformations due to variations in IOP when the device complies with the present invention is used by a user. According to a variant embodiment, the rigid element is, for example, a part, preferably in the form of a disk or ring, of the contact lens 1, which is more rigid than the rest of the contact lens, for example, by means of local thickness larger and / or local use of another material more rigid than the material used for the remainder of the preferably soft contact lens.
    [46] In the preferred embodiment illustrated in figures 1 and 2, the pressure sensor elements are mounted on a substrate 10, for example, a polyimide film, and the pressure sensor is incorporated or embedded in the material that forms the lens. contact 1. In a variant embodiment, the pressure sensor, with or without substrate, is glued or otherwise affixed to one side of the contact lens 1, preferably to its external convex side.
    [47] In the preferred embodiment shown in Figure 1, the parts of the active pressure gauge 2, the passive gauge 3 and the rigid element 4 that are located around the center C of the contact lens are essentially made up of one or more circular segments . Other forms, however, are possible within the scope of the present invention. In particular, these elements can be essentially polygonal, for example, a hexagon, octagon or dodecagon part. Figure 3, for example, shows a variant embodiment of the device according to the present invention, in which the parts of the active pressure gauge 2, the passive gauge 3 and the rigid element 4 which are located around the center C of the lens contact points are made with a plurality of straight lines that form polygons. In this example, each of these parts is configured in the form of one or more concentric polygons, particularly as one or more regular hexagons almost complete. The hexagons are only partially complete because a segment of the contact lens 1 accommodates the radial connections of the gauges 2, 3 and the rigid element 4 of the microprocessor 5.
    [48] Figure 4 shows illustrative examples, but not additional limiters of possible configurations or shapes for the parts of the active pressure gauge 2, the passive gauge 3 and / or the rigid element 4 that are located around the center C.
    [49] Preferably, the active pressure gauge 2 and the passive gauge 3 are made of any sufficiently conductive material, in such a way that variations in their resistance due to small deformations can still be reliably measured with the usual methods. This material can be any conductive metal, an alloy comprising one or more of these metals, polysilicon or semiconductor material. In a preferred embodiment, the active pressure gauge 2 and the passive gauge 3 are made of platinum. Rigid element 4 is possibly made of the same material as meters 2, 3, particularly if it also has an electrical function in addition to the mechanical one. The substrate 10 is preferably made of non-conductive material, such as polyimide, parylene or benzocyclobutene (BCB).
    [50] Preferably, the active pressure gauge 2 and the passive gauge 3 have sections 10 to 100 micrometers wide and 100 to 500 nanometers thick, most preferably 10 to 20 micrometers wide and 100 to 200 nanometers wide. thickness. According to the embodiment illustrated in figures 1 and 2, each conductor of the rigid element 4 preferably has a section 50 to 500 micrometers wide and 1 to 50 micrometers thick, most preferably 150 to 250 micrometers wide and 5 to 15 nanometers thick. The thickness of the substrate 10, if any, is preferably 1 to 500 micrometers and, preferably even greater, 5 to 10 micrometers. The use of other shapes, sections and / or thicknesses, however, is possible within the scope of the present invention.
    [51] For readability and simplicity, the pressure monitoring device of the present invention illustrated in Figure 1 comprises an active pressure gauge 2 and a passive pressure gauge 3. It is, however, possible, within the scope of the present invention. , provide a pressure sensor according to the invention with two or more active and / or passive pressure gauges. Particularly, according to an advantageous configuration, the pressure sensor of the pressure monitoring device of the invention comprises two passive gauges and two active pressure gauges that are interconnected in a Wheatstone bridge configuration, in order to allow more efficient and reliable measurement of variations of IOP.
    [52] For the sake of readability and simplicity of the figures, the active pressure gauge 2 and the passive pressure gauge 3 are illustrated in their simplest form, that is, their part located around the center C of the contact lens 1 is made of a single conductor that is electrically connected on both ends with microprocessor 5. It is possible, however, within the scope of the invention, to configure the part of the active and / or passive meters located around the center C with two or more circuits concentric, each around the center C at an angle of at least 180 °, preferably at least 270 °.
    [53] This is illustrated in figure 5b by way of an illustrative example, but by no means limiting a correspondingly configured active or passive meter 2, 3. In this example, the portion of meter 2, 3 that is configured for at least partly surrounding the center of the contact lens is made up of two concentric circular segments that are connected together on one side and configured for connection to the microprocessor on the other side. In this example, meter 2, 3 therefore comprises two concentric circuits to surround, at least in part, the center of the contact lens and is configured to connect with both ends on the same side to microprocessor 5. An advantage of this configuration is the fact that, by increasing the number of circuits of the meter part 2, 3 that is configured to surround, at least in part, the center of the contact lens, the overall length of the pressure meter 2, 3 is increased , in order to increase its sensitivity to mechanical deformations. Another advantage is the fact that the area A defined by the electrical conductor of meter 2, 3 is significantly reduced compared to the area defined by the meter conductor illustrated, for example, in Figure 5a, in order to reduce the sensitivity of the meter 2, 3 of Figure 5b for electromagnetic disturbances that may induce electrical currents in meter 2, 3 and, therefore, disturb the measurement of variations in their electrical properties due to mechanical deformations.
    [54] Figure 6 is a schematic representation of a typical intraocular pressure monitoring system using the invention's intraocular pressure monitoring device. According to the illustrated embodiment, the intraocular pressure monitoring system comprises the intraocular pressure monitoring device of the invention in the form of a contact lens 1 with a pressure sensor, a portable recording device 6 for communication with the pressure monitoring device intraocular and storage of the information collected during the IOP monitoring phases and a computing device 7, such as a personal computer, to store, analyze, compute and / or display the data collected and stored by the portable communication device 6.
    [55] The portable recording device 6 comprises a first communication interface for communicating with the invention's intraocular pressure monitoring device. The first communication interface is, for example, a wireless communication interface comprising an antenna 60 which is conveniently placed close to the contact lens 1 when the intraocular pressure monitoring device of the invention is used by a user. Antenna 60 is, for example, integrated with ocular lenses, not shown in the figures, and / or in a hypoallergenic, flexible and preferably disposable patch, also not represented in the figures, which is or is used by the user during the monitoring periods. IOP. Other means, however, are possible within the scope of the invention for placing the antenna 60 at an appropriate distance from the invention's intraocular pressure monitoring device when used by the user. The portable recording device 6 further comprises a second communication interface for communicating with the computing device 7.
    [56] When monitoring IOP, the user uses the intraocular pressure monitoring device of the invention by placing contact lens 1 over his eye, just like any ordinary contact lens, and carries the portable recording device 6, for example, in a pocket or hanging around your neck. The antenna 60 is placed as close as possible to the eye of the user using the contact lens 1, in order to allow the establishment of a first wireless communication channel 15 between the intraocular pressure monitoring device and the recording device 6 Preferably, antenna 60 is additionally oriented in a plane as parallel as possible to the antenna plane of the intraocular pressure monitoring device of the invention, in order to allow efficient supply of the pressure sensor through the communication channel 15, which is , for example, an inductive communication channel at close distance 15. The antenna is, for example, integrated into ocular lenses and / or a patch, preferably a hypoallergenic, flexible and disposable patch, around the eye and / or in a hat or other garment or accessory worn by the user. Preferably, the antenna 60 is centralized with the antenna of the intraocular pressure monitoring device of the invention when the eye pressure monitoring device and the portable recording device 6 are used by the user. The antenna diameter 60 of the portable recording device 6 is preferably larger than the diameter of the intraocular pressure monitoring device. The shape of the antenna 60 of the portable recording device 6 is, for example, round, oval, rectangular or any other suitable shape. The antenna shape 60 of the portable recording device 6 is preferably adapted to the shape of the device, such as eyepiece lenses, plaster, garment etc. to which it is attached.
    [57] According to a preferred embodiment, during IOP monitoring, the portable recording device 6 feeds the intraocular pressure monitoring device through the first communication channel 15 at intervals preferably in regular spaces and collects data sent by the microprocessor through the antenna of the intraocular pressure monitoring device. The data collected comprises, for example, electrical resistance values from the pressure sensor meters and / or a calculated IOP value. The collected data is stored in the internal memory of the portable recording device 6. The intraocular pressure is measured, for example, at a frequency of 10 to 20 Hz for ten to sixty seconds every five to ten minutes. This allows for accurate monitoring of IOP variations over extended periods of time, including at night, while the user is sleeping.
    [58] At certain times, preferably defined in advance, such as once a day, once a week or once a month, the user and / or a practitioner connects the portable recording device 6 to a computing device 7, for example example, a personal computer, by means of a second communication channel, preferably wireless, 16, for example, a Bluetooth communication channel. The second communication channel 16 can, however, also be a wired communication channel, such as USB or any other appropriate communication channel. The data collected and stored in the internal memory of the portable recording device 6 are then transferred via the second communication channel 16 to the computing device 7 for further analysis and / or computing by the user and / or the practitioner.
    权利要求:
    Claims (14)
    [0001]
    1. INTRAOCULAR PRESSURE MONITORING DEVICE comprising a soft contact lens (1) and a pressure sensor attached to the mentioned contact lens (1), said pressure sensor comprises: - an active pressure meter (2), for detecting deformations of the user's eyeball due to variations in the user's intraocular pressure, - a passive pressure gauge (3), insensitive to deformations of the eyeball due to variations in the user's intraocular pressure, - a rigid element (4), - a microprocessor, mentioned active pressure gauge (2), passive pressure gauge (3) and rigid element (4) are placed at a distance from the center (C) of the contact lens, said active pressure gauge (2) comprises a part that surrounds said center (C) of the contact lens (1) by at least 180 °, characterized by the fact that each of the said passive pressure gauge (3) and said rigid element (4) comprises a part surrounding the men center (C) of the contact lens (1) at least 180 °, and the aforementioned part of said passive pressure gauge (3) located around said center (C) of the contact lens (1) is placed in the immediate proximity of said part of said rigid element (4) located around said center (C) of said lens (1).
    [0002]
    2. INTRAOCULAR PRESSURE MONITORING DEVICE according to claim 1, characterized by the fact that said active pressure gauge (2) comprises a part that surrounds said center (C) by at least 270 °.
    [0003]
    3. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 2, characterized by the fact that each of the aforementioned passive pressure gauge (3) and said rigid element (4) comprises a part that surrounds the mentioned center (C) at least 270 °.
    [0004]
    4. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 3, characterized by the fact that the mentioned part of the said passive pressure gauge (3) that surrounds said center (C) comprises a circular segment.
    [0005]
    5. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 3, characterized in that the aforementioned part of said passive pressure gauge (3) that surrounds said center (C) comprises a plurality of rectilinear segments .
    [0006]
    6. INTRAOCULAR PRESSURE MONITORING DEVICE according to claim 5, characterized by the fact that the mentioned plurality of rectilinear segments forms a part of a regular polygon.
    [0007]
    7. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 6, characterized by the fact that the mentioned active pressure gauge (2), passive pressure gauge (3) and rigid element (4) are concentric.
    [0008]
    8. INTRAOCULAR PRESSURE MONITORING DEVICE according to claim 7, characterized by the fact that said passive pressure gauge (3) is closer to said center (C) of said contact lens (1) than said gauge pressure switch (2).
    [0009]
    9. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 8, characterized by the fact that said rigid element (4) is an antenna that allows wireless communication between said microprocessor (5) and an external device (6) and / or which allows feeding said microprocessor (5).
    [0010]
    10. INTRAOCULAR PRESSURE MONITORING DEVICE according to any one of claims 1 to 9, characterized by the fact that said rigid element is a fiber or synthetic element.
    [0011]
    11. KIT characterized by the fact that it comprises: - a pressure monitoring device according to any one of claims 1 to 10; - a portable recording device (6) configured to communicate with said pressure monitoring device and to store data received from said pressure monitoring device.
    [0012]
    KIT according to claim 11, characterized in that said portable recording device (6) is configured to supply said pressure monitoring device via an inductive wireless communication channel (15).
    [0013]
    13. INTRAOCULAR PRESSURE MONITORING SYSTEM characterized by the fact that it comprises: - a pressure monitoring device according to any of claims 1 to 10; - a portable recording device (6) configured for communication with said pressure monitoring device and for storing data received from said pressure monitoring device; and - a computing device (7) configured to communicate with said portable recording device (6) for receiving and / or processing and / or storing data received from said portable recording device (6).
    [0014]
    14. INTRAOCULAR PRESSURE MONITORING SYSTEM according to claim 13, characterized by the fact that said portable recording device (6) is configured to power said pressure monitoring device through an inductive wireless communication channel (15).
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    同族专利:
    公开号 | 公开日
    CA2784934C|2017-10-17|
    AU2011204668A1|2012-07-12|
    ES2425931T3|2013-10-18|
    CA2784934A1|2011-07-14|
    BR112012016419A2|2020-09-01|
    US20130041245A1|2013-02-14|
    AU2011204668B2|2014-09-04|
    KR101360402B1|2014-02-10|
    SG181956A1|2012-08-30|
    US9968254B2|2018-05-15|
    CN102695449B|2014-10-08|
    JP5658281B2|2015-01-21|
    CN102695449A|2012-09-26|
    HK1173355A1|2013-05-16|
    KR20120104337A|2012-09-20|
    RU2550688C2|2015-05-10|
    JP2013516255A|2013-05-13|
    WO2011083105A1|2011-07-14|
    RU2012125665A|2014-02-20|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US3769961A|1972-07-20|1973-11-06|I Fatt|Conjunctival device|
    US3958560A|1974-11-25|1976-05-25|Wayne Front March|Non-invasive automatic glucose sensor system|
    US4089329A|1976-03-18|1978-05-16|University Of Utah Research Institute|Noninvasive, continuous intraocular pressure monitor|
    US4922913A|1987-11-12|1990-05-08|Waters Jr George E|Intraocular pressure sensor|
    US5005577A|1988-08-23|1991-04-09|Frenkel Ronald E P|Intraocular lens pressure monitoring device|
    JPH0545284Y2|1991-02-05|1993-11-18|
    JPH08136378A|1994-11-07|1996-05-31|Tec Corp|Thin-film gauge pressure sensor|
    JPH09178580A|1995-12-27|1997-07-11|Bridgestone Corp|Load measuring apparatus|
    US6120460A|1996-09-04|2000-09-19|Abreu; Marcio Marc|Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions|
    JP2001524212A|1997-03-24|2001-11-27|インテグレーテッドマイクロマシーンズ，インコーポレーテッド|Batch assembled semiconductor thin film pressure sensor and method of manufacturing the same|
    DE19728069C1|1997-07-01|1999-02-11|Acritec Gmbh|Device for measuring intraocular pressure|
    US6193656B1|1999-02-08|2001-02-27|Robert E. Jeffries|Intraocular pressure monitoring/measuring apparatus and method|
    JP2000292295A|1999-04-05|2000-10-20|Tokin Corp|Inner pressure sensor for enclosed container|
    DE19945879C2|1999-09-24|2002-01-03|Acritec Gmbh|Device for measuring the intraocular pressure with a foldable implant|
    US6579235B1|1999-11-01|2003-06-17|The Johns Hopkins University|Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder|
    US6939299B1|1999-12-13|2005-09-06|Kurt Petersen|Implantable continuous intraocular pressure sensor|
    AU5504601A|2000-05-08|2001-11-20|Ness Tec Ophthalmic Systems Ltd.|Intraocular pressure measurement|
    US6749568B2|2000-08-21|2004-06-15|Cleveland Clinic Foundation|Intraocular pressure measurement system including a sensor mounted in a contact lens|
    US6447449B1|2000-08-21|2002-09-10|Cleveland Clinic Foundation|System for measuring intraocular pressure of an eye and a MEM sensor for use therewith|
    US7024248B2|2000-10-16|2006-04-04|Remon Medical Technologies Ltd|Systems and methods for communicating with implantable devices|
    JP5079970B2|2001-06-29|2012-11-21|エコールポリテクニークフェデラルドゥローザンヌ（エーペーエフエル）|Intraocular pressure recording device|
    US20030078487A1|2001-08-09|2003-04-24|Jeffries Robert E.|Ocular pressure measuring device|
    US20070123767A1|2002-05-31|2007-05-31|Valentino Montegrande|Intraocular pressure sensor and method of use|
    JP4362590B2|2005-02-25|2009-11-11|国立大学法人大分大学|Full-field light stimulator|
    GB2420628B|2005-09-27|2006-11-01|Toumaz Technology Ltd|Monitoring method and apparatus|
    US20090203985A1|2005-10-14|2009-08-13|Ehrecke Timothy J|Pressure Monitor|
    WO2007136993A1|2006-05-17|2007-11-29|Mayo Foundation For Medical Education And Research|Monitoring intraocular pressure|
    CN100448391C|2007-01-23|2009-01-07|天津市索维电子技术有限公司|Intraocular tension monitoring device|
    RU2335234C1|2007-03-28|2008-10-10|Олег Леонидович Головков|Method of measuring of intraocular pressure through eye-lid and device for its realisation |
    CA2695454C|2007-08-23|2016-09-20|Purdue Research Foundation|Intra-ocular pressure sensor|
    CA2702770C|2007-10-19|2018-02-13|Sensimed Ag|Intraocular pressure monitoring device|
    WO2009111726A2|2008-03-06|2009-09-11|The Regents Of The University Of California|Measuring outlflow resistance/facility of an eye|
    ES2330405B1|2008-06-06|2010-09-21|Consejo Superior De Investigaciones Cientificas |SENSOR CONTACT LENS, SYSTEM FOR NON-INVASIVE MONITORING OF INTRAOCULAR PRESSURE AND METHOD TO PUT YOUR MEASUREMENT.|
    CN102264277B|2008-07-09|2015-04-29|劳伦斯·M·麦金利|Optic function monitoring process and apparatus|
    US20100324476A1|2009-06-17|2010-12-23|Mikhail Boukhny|Fluidics control via wireless telemetry|US7864151B1|1986-07-07|2011-01-04|Semiconductor Energy Laboratory Co., Ltd.|Portable electronic device|
    US9823737B2|2008-04-07|2017-11-21|Mohammad A Mazed|Augmented reality personal assistant apparatus|
    CA2702770C|2007-10-19|2018-02-13|Sensimed Ag|Intraocular pressure monitoring device|
    US9675443B2|2009-09-10|2017-06-13|Johnson & Johnson Vision Care, Inc.|Energized ophthalmic lens including stacked integrated components|
    US8950862B2|2011-02-28|2015-02-10|Johnson & Johnson Vision Care, Inc.|Methods and apparatus for an ophthalmic lens with functional insert layers|
    US9698129B2|2011-03-18|2017-07-04|Johnson & Johnson Vision Care, Inc.|Stacked integrated component devices with energization|
    US10451897B2|2011-03-18|2019-10-22|Johnson & Johnson Vision Care, Inc.|Components with multiple energization elements for biomedical devices|
    US9889615B2|2011-03-18|2018-02-13|Johnson & Johnson Vision Care, Inc.|Stacked integrated component media insert for an ophthalmic device|
    US9804418B2|2011-03-21|2017-10-31|Johnson & Johnson Vision Care, Inc.|Methods and apparatus for functional insert with power layer|
    IL224797A|2012-02-22|2017-03-30|Johnson & Johnson Vision Care|Ophthalmic lens with segmented ring layers in a functionalized insert|
    US9271677B2|2011-10-05|2016-03-01|Sensimed Sa|Intraocular pressure measuring and/or monitoring device|
    EP2812826A1|2012-02-10|2014-12-17|Johnson & Johnson Vision Care Inc.|A lens storage unit with programmable and communication elements for monitoring the condition of lenses and their response to geo-social phenomena|
    US8857983B2|2012-01-26|2014-10-14|Johnson & Johnson Vision Care, Inc.|Ophthalmic lens assembly having an integrated antenna structure|
    US9125724B2|2012-03-09|2015-09-08|John Berdahi|Intraocular pressure modification|
    US8798332B2|2012-05-15|2014-08-05|Google Inc.|Contact lenses|
    EP2852318B1|2012-05-21|2016-10-12|Sensimed SA|Intraocular pressure measuring and/or monitoring system with inertial and/or environmental sensor|
    US9158133B1|2012-07-26|2015-10-13|Google Inc.|Contact lens employing optical signals for power and/or communication|
    US9298020B1|2012-07-26|2016-03-29|Verily Life Sciences Llc|Input system|
    US9523865B2|2012-07-26|2016-12-20|Verily Life Sciences Llc|Contact lenses with hybrid power sources|
    US8857981B2|2012-07-26|2014-10-14|Google Inc.|Facilitation of contact lenses with capacitive sensors|
    US8919953B1|2012-08-02|2014-12-30|Google Inc.|Actuatable contact lenses|
    US9696564B1|2012-08-21|2017-07-04|Verily Life Sciences Llc|Contact lens with metal portion and polymer layer having indentations|
    US8971978B2|2012-08-21|2015-03-03|Google Inc.|Contact lens with integrated pulse oximeter|
    US9111473B1|2012-08-24|2015-08-18|Google Inc.|Input system|
    US8820934B1|2012-09-05|2014-09-02|Google Inc.|Passive surface acoustic wave communication|
    US20140192315A1|2012-09-07|2014-07-10|Google Inc.|In-situ tear sample collection and testing using a contact lens|
    US9398868B1|2012-09-11|2016-07-26|Verily Life Sciences Llc|Cancellation of a baseline current signal via current subtraction within a linear relaxation oscillator-based current-to-frequency converter circuit|
    US10010270B2|2012-09-17|2018-07-03|Verily Life Sciences Llc|Sensing system|
    US9326710B1|2012-09-20|2016-05-03|Verily Life Sciences Llc|Contact lenses having sensors with adjustable sensitivity|
    US8960898B1|2012-09-24|2015-02-24|Google Inc.|Contact lens that restricts incoming light to the eye|
    US8870370B1|2012-09-24|2014-10-28|Google Inc.|Contact lens that facilitates antenna communication via sensor impedance modulation|
    US20140088372A1|2012-09-25|2014-03-27|Google Inc.|Information processing method|
    US8989834B2|2012-09-25|2015-03-24|Google Inc.|Wearable device|
    US8979271B2|2012-09-25|2015-03-17|Google Inc.|Facilitation of temperature compensation for contact lens sensors and temperature sensing|
    US9884180B1|2012-09-26|2018-02-06|Verily Life Sciences Llc|Power transducer for a retinal implant using a contact lens|
    US8821811B2|2012-09-26|2014-09-02|Google Inc.|In-vitro contact lens testing|
    US8960899B2|2012-09-26|2015-02-24|Google Inc.|Assembling thin silicon chips on a contact lens|
    US8985763B1|2012-09-26|2015-03-24|Google Inc.|Contact lens having an uneven embedded substrate and method of manufacture|
    US9063351B1|2012-09-28|2015-06-23|Google Inc.|Input detection system|
    US8965478B2|2012-10-12|2015-02-24|Google Inc.|Microelectrodes in an ophthalmic electrochemical sensor|
    US9176332B1|2012-10-24|2015-11-03|Google Inc.|Contact lens and method of manufacture to improve sensor sensitivity|
    US9757056B1|2012-10-26|2017-09-12|Verily Life Sciences Llc|Over-molding of sensor apparatus in eye-mountable device|
    TWI494638B|2012-12-12|2015-08-01|Univ Nat Taiwan|Monitoring system for change in intraocular pressure , method thereof, and contact lenses for sensing change in iop|
    US8874182B2|2013-01-15|2014-10-28|Google Inc.|Encapsulated electronics|
    US9289954B2|2013-01-17|2016-03-22|Verily Life Sciences Llc|Method of ring-shaped structure placement in an eye-mountable device|
    FR3001377B1|2013-01-25|2015-01-23|Ophtimalia|INTEGRATED FLEXIBLE PASSIVE SENSOR CONTACT LENS|
    US20140209481A1|2013-01-25|2014-07-31|Google Inc.|Standby Biasing Of Electrochemical Sensor To Reduce Sensor Stabilization Time During Measurement|
    US9636016B1|2013-01-25|2017-05-02|Verily Life Sciences Llc|Eye-mountable devices and methods for accurately placing a flexible ring containing electronics in eye-mountable devices|
    FR3001378B1|2013-01-25|2015-01-23|Ophtimalia|INTEGRATED FLEXIBLE PASSIVE SENSOR CONTACT LENS|
    US9161712B2|2013-03-26|2015-10-20|Google Inc.|Systems and methods for encapsulating electronics in a mountable device|
    US9113829B2|2013-03-27|2015-08-25|Google Inc.|Systems and methods for encapsulating electronics in a mountable device|
    CN105229516A|2013-05-02|2016-01-06|索尼公司|Contact lenses and recording medium|
    US9429769B2|2013-05-09|2016-08-30|Johnson & Johnson Vision Care, Inc.|Ophthalmic device with thin film nanocrystal integrated circuits|
    US20140371560A1|2013-06-14|2014-12-18|Google Inc.|Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device|
    US9084561B2|2013-06-17|2015-07-21|Google Inc.|Symmetrically arranged sensor electrodes in an ophthalmic electrochemical sensor|
    US9948895B1|2013-06-18|2018-04-17|Verily Life Sciences Llc|Fully integrated pinhole camera for eye-mountable imaging system|
    US9685689B1|2013-06-27|2017-06-20|Verily Life Sciences Llc|Fabrication methods for bio-compatible devices|
    US9307901B1|2013-06-28|2016-04-12|Verily Life Sciences Llc|Methods for leaving a channel in a polymer layer using a cross-linked polymer plug|
    US9028772B2|2013-06-28|2015-05-12|Google Inc.|Methods for forming a channel through a polymer layer using one or more photoresist layers|
    US9814387B2|2013-06-28|2017-11-14|Verily Life Sciences, LLC|Device identification|
    US8922366B1|2013-06-28|2014-12-30|Google Inc.|Reader communication with contact lens sensors and display device|
    US9901247B2|2013-06-28|2018-02-27|Verily Life Sciences Llc|Methods for adhering a substrate to a polymer layer|
    US9492118B1|2013-06-28|2016-11-15|Life Sciences Llc|Pre-treatment process for electrochemical amperometric sensor|
    US9251455B2|2013-08-22|2016-02-02|Verily Life Sciences Llc|Using unique identifiers to retrieve configuration data for tag devices|
    US9192298B2|2013-09-06|2015-11-24|Syntec Optics|Contact lens for intraocular pressure measurement|
    US9225375B2|2013-09-23|2015-12-29|Johnson & Johnson Vision Care, Inc.|Ophthalmic lens system capable of wireless communication with multiple external devices|
    EP3069652B1|2013-11-15|2019-12-11|Ubiquity Biomedical Corporation|Eye temperature measurement and analysis system, receiving and analysis device|
    CN104586348A|2013-10-31|2015-05-06|赖弘基|System for measuring and analyzing ocular temperature, receiving analyzer and methods for using the same|
    US9526411B2|2013-10-31|2016-12-27|Horng Ji Lai|System for measuring and analyzing ocular temperature, receiving analyzer and methods for using the same|
    US20150148648A1|2013-11-22|2015-05-28|Johnson & Johnson Vision Care, Inc.|Ophthalmic lens with intraocular pressure monitoring system|
    US9289123B2|2013-12-16|2016-03-22|Verily Life Sciences Llc|Contact lens for measuring intraocular pressure|
    US9572522B2|2013-12-20|2017-02-21|Verily Life Sciences Llc|Tear fluid conductivity sensor|
    US9654674B1|2013-12-20|2017-05-16|Verily Life Sciences Llc|Image sensor with a plurality of light channels|
    US9366570B1|2014-03-10|2016-06-14|Verily Life Sciences Llc|Photodiode operable in photoconductive mode and photovoltaic mode|
    US9184698B1|2014-03-11|2015-11-10|Google Inc.|Reference frequency from ambient light signal|
    US9789655B1|2014-03-14|2017-10-17|Verily Life Sciences Llc|Methods for mold release of body-mountable devices including microelectronics|
    JP2017520337A|2014-07-01|2017-07-27|インジェクトセンス， インコーポレイテッド|Ultra-low power rechargeable implantable sensor with wireless interface for patient monitoring|
    EP2979622A1|2014-07-31|2016-02-03|Ophtimalia|Passive sensing means for a contact lens|
    CN107072528B|2014-08-20|2021-07-02|加州浸会大学|System and method for monitoring eye health|
    US10381687B2|2014-08-21|2019-08-13|Johnson & Johnson Vision Care, Inc.|Methods of forming biocompatible rechargable energization elements for biomedical devices|
    US9793536B2|2014-08-21|2017-10-17|Johnson & Johnson Vision Care, Inc.|Pellet form cathode for use in a biocompatible battery|
    US10627651B2|2014-08-21|2020-04-21|Johnson & Johnson Vision Care, Inc.|Methods and apparatus to form biocompatible energization primary elements for biomedical devices with electroless sealing layers|
    US10361405B2|2014-08-21|2019-07-23|Johnson & Johnson Vision Care, Inc.|Biomedical energization elements with polymer electrolytes|
    US9599842B2|2014-08-21|2017-03-21|Johnson & Johnson Vision Care, Inc.|Device and methods for sealing and encapsulation for biocompatible energization elements|
    US9941547B2|2014-08-21|2018-04-10|Johnson & Johnson Vision Care, Inc.|Biomedical energization elements with polymer electrolytes and cavity structures|
    US10361404B2|2014-08-21|2019-07-23|Johnson & Johnson Vision Care, Inc.|Anodes for use in biocompatible energization elements|
    US9715130B2|2014-08-21|2017-07-25|Johnson & Johnson Vision Care, Inc.|Methods and apparatus to form separators for biocompatible energization elements for biomedical devices|
    US9383593B2|2014-08-21|2016-07-05|Johnson & Johnson Vision Care, Inc.|Methods to form biocompatible energization elements for biomedical devices comprising laminates and placed separators|
    KR101559568B1|2014-08-29|2015-10-15|한국과학기술연구원|Integrated ocular sensor and method for manufacturing and controlling the same|
    EP3017749A1|2014-11-06|2016-05-11|Ophtimalia|Passive sensing means for a physiological parameter monitoring system|
    EP3017751B1|2014-11-06|2020-10-21|Ophtimalia|Physiological parameter monitoring device|
    EP3017750A1|2014-11-06|2016-05-11|Ophtimalia|Passive sensing means for a physiological parameter monitoring system|
    CN104473616A|2014-12-18|2015-04-01|上海市同济医院|Contact lens for continuously and dynamically monitoring intraocular pressure|
    WO2016183646A1|2015-05-15|2016-11-24|Lage Ângela Giovanna Fiorita|Intraocular lens - prosthesis - with embedded intraocular pressure-measuring device|
    CA2995240A1|2015-08-14|2017-02-23|Ivantis, Inc.|Ocular implant with pressure sensor and delivery system|
    US20170049395A1|2015-08-20|2017-02-23|Zansors Llc|Neuro-vigilance integrated contact eye lens and system|
    CN113842266A|2015-08-27|2021-12-28|伊奎诺克斯眼科公司|Apparatus for at least one of diagnosing or treating an eye condition|
    US10345620B2|2016-02-18|2019-07-09|Johnson & Johnson Vision Care, Inc.|Methods and apparatus to form biocompatible energization elements incorporating fuel cells for biomedical devices|
    US20180239422A1|2017-02-17|2018-08-23|International Business Machines Corporation|Tracking eye movements with a smart device|
    CN106821305A|2017-03-23|2017-06-13|清华大学|A kind of intraocular pressure monitoring device|
    US10898074B2|2017-09-09|2021-01-26|Smartlens, Inc.|Closed microfluidic network for strain sensing embedded in a contact lens to monitor intraocular pressure|
    US11143885B2|2017-09-25|2021-10-12|Verily Life Sciences Llc|Smart contact lens with antenna and sensor|
    CN107822589B|2017-12-17|2019-05-31|华中科技大学|A kind of intraocular pressure sensor and tonometry device based on optical fiber FPI|
    CN108692670B|2018-05-30|2020-08-11|业成科技（成都）有限公司|Strain monitoring method for curved surface fitting|
    KR102075143B1|2018-06-08|2020-03-02|울산과학기술원|Smart contact lens for monitoring intraocular pressure and manufacturing method of the same|
    US20210307609A1|2018-07-25|2021-10-07|Qura, Inc.|Implantable intraocular pressure sensors configured as capsular tension rings|
    CN110200586A|2019-04-04|2019-09-06|清华大学|A kind of intraocular pressure monitoring sensor|
    WO2020236139A1|2019-05-17|2020-11-26|Qura, Inc.|Intraocular lenses with intraocular pressure sensors and methods of manufacture|
    EP3861924A1|2020-02-07|2021-08-11|Alfa Intes Industria Terapeutica Splendore S.r.l.|Contact lens device and related pressure monitoring kit and system comprising the same|
    法律状态:
    2020-09-15| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|
    2020-11-17| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|
    2020-12-29| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/01/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    EPPCT/EP2010/050062|2010-01-05|
    EP2010050062|2010-01-05|
    PCT/EP2011/050038|WO2011083105A1|2010-01-05|2011-01-03|Intraocular pressure monitoring device|
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